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論文
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外部資金
科研費研究者番号
(最終更新日:2022-09-28 08:04:19)
イナダ シン
Shin Inada
稲田 慎
所属
森ノ宮医療大学 医療技術学部 臨床工学科
森ノ宮医療大学大学院 保健医療学研究科 保健医療学専攻
森ノ宮医療大学大学院 保健医療学研究科 医療科学専攻
職種
教授
■
職歴
1.
2002/04~2004/03
東京電機大学 助手
2.
2004/04~2005/03
東京電機大学 研究員
3.
2004/04~2005/02
英国リーズ大学 研究員
4.
2005/02~2010/08
英国マンチェスター大学 研究員
5.
2010/09~2011/03
国立循環器病研究センター研究所 文部科学特任研究員
6.
2011~2012
大阪大学大学院 基礎工学研究科 非常勤講師
7.
2011/04~2016/03
国立循環器病研究センター研究所 特任研究員
8.
2013~2016
兵庫県立大学大学院 社会応用情報科学研究センター プロジェクト研究員
9.
2014~2016
姫路獨協大学 非常勤講師
10.
2016~
国立循環器病研究センター 客員研究員
11.
2016/04~2018/03
姫路獨協大学 医療保健学部 准教授
12.
2018/04~
姫路獨協大学 医療保健学部 非常勤講師
5件表示
全件表示(12件)
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専門分野
生体医工学, 計算科学, 電気生理学
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研究テーマ
1.
コンピュータシミュレーションを用いた不整脈発生・維持メカニズムの解析
2.
心電図解析による不整脈発生メカニズムの解析
■
所属学会
1.
2010/09~
日本不整脈心電学会
2.
2011/07~
日本生体医工学会
3.
2018/12~2020
∟ 代議員
4.
2012/04~
日本循環器学会
■
受賞学術賞
1.
2004/04
日本生体医工学会論文賞・阪本賞
2.
1997/03
日本機械学会畠山賞
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論文
1.
論文
Simulation of ventricular rate control during atrial fibrillation using ionic channel blockers. Journal of Arrhythmia. (共著) 2017
2.
論文
Splicing misregulation of SCN5A contributes to cardiac conduction delay and heart arrhythmia in myotonic dystrophy. Nature Communications, (No.7),pp.11067 (共著) 2016
3.
論文
Characterization and influence of cardiac background sodium current in the atrioventricular node. Journal of Molecular and Cellular Cardiology. Vol.97,pp.114-124 (共著) 2016
4.
論文
三次元心臓モデルのリアルタイム形状変形を実現するマルチタッチインタラクションシステムの技術開発 医療情報学 34(5),221-232頁 (共著) 2014
5.
論文
Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours. PLOS ONE. 9(11),pp.e112547 (共著) 2014
6.
論文
Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing. PLOS ONE. 9(4),pp.e94565 (共著) 2014
7.
論文
Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate. Hypertension. 64(6),pp.1334-1343 (共著) 2014
8.
論文
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissue. Pharmacology and Therapeutics. 139(2),pp.260-288 (共著) 2013
9.
論文
Connexins and the atrioventricular node. Heart Rhythm. 10(2),pp.297-304 (共著) 2013
10.
論文
Pharmacological blockade of
I
Ks
destabilizes spiral-wave reentry under beta-adrenergic stimulation in favors of its early termination. Journal of Pharmacological Sciences. 119(1),pp.52-63 (共著) 2012
11.
論文
Molecular architecture of the human specialised atrioventricular conduction axis. Journal of Molecular and Cellular Cardiology. 50(4),pp.642-651 (共著) 2011
12.
論文
Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area. Anatomical Records. 294(6),pp.970-979 (共著) 2011
13.
論文
Anatomical and molecular mapping of the left and right ventricular His-Purkinje conduction networks. Journal of Molecular and Cellular Cardiology. 51(5),pp.689-701 (共著) 2011
14.
論文
Ageing-dependent remodelling of ion channel and Ca
2+
clock genes underlying sino-atrial node pacemaking. Experimental Physiology. 96(11),pp.1163-1178 (共著) 2011
15.
論文
Mechanistic links between Na
+
channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circulation Research. 107(1),pp.126-137 (共著) 2010
16.
論文
One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-His cells. Biophysical Journal. 97(8),2117-2127頁 (共著) 2009
17.
論文
Molecular architecture of the human sinus node. Insights into the function of the cardiac pacemaker. Circulation. 119(12),pp.1562-1575 (共著) 2009
18.
論文
Computer three-dimensional reconstruction of the atrioventricular node. Circulation Research. 102(8),pp.975-985 (共著) 2008
19.
論文
Atrial proarrhythmia due to increase inward rectifier current (
I
K1
) arising from KCNJ2 mutation. a simulation study. Progress in Biophysics and Molecular Biology. 98,pp.186-197 (共著) 2008
20.
論文
Imaging the heart: computer 3-dimensional anatomic models of the heart. Journal of Electrocardiology. 38,pp.113-120 (共著) 2005
21.
論文
SR Ca
2+
release is not a dominant factor in sinoatrial node pacemaker activity. Circulation Research. 92(3),pp.e41-e44 (共著) 2003
22.
論文
Pacing-induced repetitive excitations in myocardial sleeves of pulmonary veins after treatment with ryanodine. Circulation. 107(14),pp.1937-1943 (共著) 2003
23.
論文
Modified bipolar electrode を用いた洞結節細胞外電位マッピングシステムの開発. 生体医工学 (Transactions of the Japanese Society for Medical and Biological Engineering) 40(3),165-177頁 (共著) 2002
24.
論文
Pacemaker shift in the rabbit sinoatrial node in response to vagal nerve stimulation. Experimental Physiology. 86(2),pp.177-184 (共著) 2001
5件表示
全件表示(24件)
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著書
1.
著書
Simulation study of ventricular rate control therapy during atrial fibrillation using one-dimensional cable model with two conduction pathways. In Kennedy J, Macfarlane PW (eds): Electrocardiology pp.117-120 (共著) 2013
2.
著書
仮想心臓シミュレーション シミュレーション辞典 45頁 (共著) 2012
3.
著書
Connexins in the sinoatrial and atrioventricular nodes. S Dhein (ed): Cardiovascular Gap Junctions. 42,pp.175-197 (共著) 2006
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総説等
1.
その他
Mechanisms of Ventricular Fibrillation: Current Status and Problems Advanced Biomedical Engineering 11,pp.117-135 (共著) 2022
2.
その他
Mechanism of Electrical Defibrillation. Current states and future perspective Advanced Biomedical Engineering 9,pp.125-137 (共著) 2020
3.
その他
房室結節における心拍制御機構の解析 ―コンピュータシミュレーションによる検討― 計測と制御 57(8),563-569頁 (共著) 2018
4.
その他
「クラッとしたら・・・そこに潜む病気解明SP」 2015/02
5.
その他
ヒトiPS細胞由来心筋細胞シートの不整脈研究への応用可能性: in silico不整脈学の観点から 生体医工学 53(3),100-105頁 (共著) 2015
6.
その他
コンピュータシミュレーションによるプルキンエ線維起源の心室性不整脈発生機序の検討 生体医工学 53(3),106-114頁 (共著) 2015
7.
その他
FSKイオンチャネルモデルを用いた心臓興奮伝播の機能的シミュレーション 生体医工学 53(3),151-159頁 (共著) 2015
8.
その他
「心臓 ふぞろいの細胞がカギ 規則正しい鼓動、なぜ?」 朝日新聞夕刊(大阪版) (単著) 2014/04
9.
その他
コンピュータシミュレーションによる洞結節不均一構造重要性の検討 循環器病研究の進歩 35(1),69-80頁 (共著) 2014
10.
その他
イオンチャネルモデルを用いた心筋組織における興奮伝播シミュレーション.フィラメント解析による抗不整脈機構の検討 医学のあゆみ. 238(3),223-228頁 (共著) 2011
11.
その他
心電図QT間隔と自律神経. 進歩する心臓研究 Tokyo Heart Journal 22(2) (共著) 2002
12.
その他
Role of Ca2+ release from sarcoplasmic reticulum in pacemaker activity of the sinoatrial node. Environmental Medicine. 46,pp.98-100 (共著) 2002
13.
その他
Pacemaker shift induced by ryanodine to ectopic atrial pacemaker located close to the atrium-pulmonary vein junction. Environmental Medicine. 45(2),pp.100-102 (共著) 2001
14.
その他
Vagal stimulation-induced pacemaker shift within the rabbit sinoatrial node. Environmental Medicine. 43(1),pp.42-44 (共著) 1999
15.
その他
Development of a new mapping system recording extracellular potentials using a modified bipolar electrode array. Environmental Medicine. 43(2),pp.136-138 (共著) 1999
5件表示
全件表示(15件)
■
学会発表
1.
2019/03/04
12誘導心電図から再構成したベクトル心電図を用いた心室性不整脈発生起源の推定 〜シミュレーションによる理論的検討〜(MEとバイオサイバネティックス研究会)
2.
2018/11/25
コンピュータシミュレーションにより再構成したベクトル心電図の不整脈発生起源同定への応用(第38回医療情報学連合大会)
3.
2018/11/25
心内心電図処理に基づく心房細動のリアルタイム可視化がもたらすカテーテルアブレーションの変革(第38回医療情報学連合大会)
4.
2018/06/28
Arrhythmogenic of right ventricular outflow tract epicardium -A simulation study-.(The 2018 International Congress on Electrocardiology)
5.
2018/06/19
Simulation study of excitation conduction using three-dimensional atrioventricular node model.(第57回日本生体医工学会大会)
6.
2017/11/20
ベクトル心電図特徴量と不整脈発生起源との関係(第37回医療情報学連合大会(第18回日本医療情報学会学術大会))
7.
2017/11/20
慢性心房細動アブレーションの新たな治療戦略に向けたインシリコの応用(第37回医療情報学連合大会(第18回日本医療情報学会学術大会))
8.
2017/09/14
AV nodal conduction during AF.(The 10th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in conjunction with the Annual Meeting of the Japanese Heart Rhythm Society (JHRS) 2017)
9.
2017/09/14
Ventricular arrhythmias initiated from conduction delay zone around right ventricular outflow tract epicardium: A simulation study.(The 10th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) in conjunction with the Annual Meeting of the Japanese Heart Rhythm Society (JHRS) 2017)
10.
2017/06/24
Analyzing vectorcardiograms synthesized from 12-lead electrocardiogram to predict the origin of sinus rhythm and premature contraction.(The 44th International Congress on Electrocardiology (ICE)/The 17th Congress of the International Society for Holter and Noninvasive Electrocardiology (ISHNE))
11.
2017/06/10
健常者と患者におけるベクトル心電図特徴量の比較検討(第32回心電情報処理ワークショップ(JSCE2017)/第27回体表心臓微小電位研究会/第14回心電図伝送システム研究会合同集会)
12.
2017/06/10
非発作性心房細動における興奮波ダイナミクスは構造的リモデリング指標よりも年齢によって規定される:ExTRa Mapping Project.(第32回心電情報処理ワークショップ(JSCE2017)/第27回体表心臓微小電位研究会/第14回心電図伝送システム研究会合同集会)
13.
2017/05/03
Analyzing vectorcardiogram synthesized from 12-lead electrocardiogram for predicting origin of premature beat.(第56回日本生体医工学会大会)
14.
2017/03/13
12誘導心電図から期外収縮発生起源同定手法の検討(MEとバイオサイバネティックス研究会)
15.
2017/01/19
影響範囲を限定した領域拡張による心臓の領域分割(日本機械学会第29回バイオエンジニアリング講演会)
16.
2016/08/27
Quickly remapping by novel online phase mapping system complemented by in silico predictions is very useful for confirming the effectiveness of non-PAF ablation (ExTRa Mapping Project)(The 38th Annual Congress of the European Society of Cardiology (ESC Congress 2016))
17.
2016/05/04
Stationary rotors are not therapeutic targets in patients with non-paroxysmal atrial fibrillation? A clinical study employing a novel "online" real-time phase mapping system (ExTRa Mapping)(Heart Rhythm 2016 Scientific Sessions)
18.
2015/11/19
Development of a novel real-time phase mapping system, called ExTRa Mapping, using in silico technique for identifying unstable rotors in patients with non-paroxysmal atrial fibrillation.(The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS))
19.
2015/11/19
No stationary rotors are observed in patients with non-paroxysmal atrial fibrillation: A combined clinical and in silico study employing a novel real-time phase mapping system (ExTRa Mapping).(The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS))
20.
2015/11/19
Rotor distribution does not always match with the anatomic distribution of complex fractionated atrial electrogram sites in patients with non-paroxysmal atrial fibrillation: A clinical observational study employing a novel real-time phase mapping system (ExTRa Mapping).(The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS))
21.
2015/06/24
Conduction delay of right ventricular outflow tract and ventricular arrhythmia -A simulation study for Brugada syndrome-.(International Congress on Electrocardiology 2015)
22.
2015/03/04
Ventricular arrhythmias generated from Purkinje fiber network with gap junction mutation -A simulation study-.(The Final HD Physiology Symposium)
23.
2014/07/26
Investigating excitation conduction in the atrioventricular node and Purkinje network using computer simulation.(The 9th Tawara-Aschoff Symposium)
24.
2013/08/07
Functional properties of complex fractionated atrial electrograms during atrial fibrillation can be explained by structural remodelling: A simulation study.(40th International Congress on Electrocardiology)
25.
2013/08/07
Simulation study of ventricular rate control therapy during atrial fibrillation using one-dimensional cable model with two conduction pathways.(40th International Congress on Electrocardiology)
26.
2013/07/03
Simulation studies of tachyarrhythmias in a 3-D ventricular wall model: implications for electrophysiological heterogeneity and rotational anisotropy.(35th Annual International IEEE EMBS Conference)
27.
2013/07/03
Simulation study of complex action potential conduction in atrioventricular node.(35th Annual International IEEE EMBS Conference)
28.
2013/06/28
Multi-scale simulation studies of excitation conduction from the sinoatrial node to the ventricles in the heart.(The 2nd HD Physiology International Symposium: Multi-Level Systems Biology)
29.
2013/06/28
Reentrant beat in the Purkinje network associated with gap junction mutation -A simulation study-.(The 2nd HD Physiology International Symposium: Multi-Level Systems Biology)
30.
2013/06/28
Rotational anisotropy prevents transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of depolarization - A simulation study -.(The 2nd HD Physiology International Symposium: Multi-Level Systems Biology)
31.
2012/10/03
Function of dual conduction pathway in atrioventricular node during Wenckebach periodicity: a simulation study.(APHRS (Asia Pacific Heart Rhythm Society Scientific Session) 2012)
32.
2012/10/03
Rotational anisotropy prevents transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of repolarization.(APHRS (Asia Pacific Heart Rhythm Society Scientific Session) 2012)
33.
2012/08/29
Dual conduction pathway in atrioventricular node acts as important roles to generate Wenckebach periodicity -A simulation study-.(8th Tawara-Aschoff-Meeting)
34.
2012/08/28
Simulation study of ventricular rate control during atrial fibrillation using cable model with two conduction pathways.(34th Annual International Conference of the IEEE EMBS)
35.
2012/08/25
Epicardial cooling increases opportunity of spiral wave termination: a simulation study.(ESC congress 2012)
36.
2012/01
Effects of Ca
2+
channel blocker and beta-blocker on ventricular rate during atrial fibrillation.(The 1st HD Physiology International Symposium: Integrative Multi-level Systems Biology for In silico Cardiology and Pharmacokinetics)
37.
2011/09
Stability of ventricular fibrillation is altered by wall deformation after the onset of fibrillation.(Asia Pacific Heart Rhythm Society Scientific Session)
38.
2011
Mechanisms of complex fractionated electrogram-targeted ablation in a model for chronic atrial fibrillation.(Asia Pacific Heart Rhythm Society Scientific Session)
39.
2011
Rotational anisotropy prevents transitions of tachycardia to fibrillation in the ventricular wall model with large transmural dispersion of repolarization: a simulation study.(Asia Pacific Heart Rhythm Society Scientific Session)
40.
2011
Simulation study of effect of antiarrhythmic drugs on ventricular rate during atrial fibrillation.(Asia Pacific Heart Rhythm Society Scientific Session)
41.
2010/08/31
The origins of heart rate variability in isolated hearts.(ESC Congress 2010)
42.
2009/04/01
Analysis of the effect of acetylcholine on the atrioventricular node.(Northern Cardiovascular Research Group Meeting 2009)
43.
2009
A modified FitzHugh-Nagumo model that allows controls of action potential duration and refractory period.(Computers in Cardiology)
44.
2009
Mathematical models of human sinus and atrioventricular node action potentials.(Computers in Cardiology)
45.
2008
Propagation in an electrophysiologically detailed 1-dimensional model of the whole rabbit heart.(Physiological Society Meeting)
46.
2008
Simulation of atrioventricular node reentry using detailed anatomical and action potential models.(Physiological Society Meeting)
47.
2007
A ‘model’ of the atrioventricular node.(Physiological Society Meeting)
48.
2007
Mathematical model of the atrioventricular node.(Physiological Society Meeting)
49.
2005
Why is Cav1.3 expressed in the sinoatrial node?(Biophysical Society 49th Annual Meeting)
50.
2004
Insights into sick sinus syndrome callused by mutation of the cardiac sodium channel gene.(Physiological Society Meeting)
51.
2003
Capacitance, coupling and the heterogeneity are key to maintaining sinus node activity.(NASPE, North American Society of Pacing and Electrophysiology 24th Annual Scientific Sessions)
52.
2002
Abnormal automaticity induced by rapid pacing in myocardial sleeves of rabbit pulmonary veins after treatment with ryanodine.(NASPE, North American Society of Pacing and Electrophysiology 23rd Annual Scientific Sessions)
53.
2002
Heterogeneity and ageing of the sinoatrial node.(Physiological Society Meeting)
54.
1999/05/21
Beat-to-beat pacemaker shift in the sinoatrial node in response to vagal stimulation.(New Strategies for Antiarrhythmia Treatment)
5件表示
全件表示(54件)
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外部資金
1.
2021/04~
位相シンギュラリティに基づく心房細動のダイナミクス変容とロバスト性に関する研究 基盤研究(C)
2.
2020/04~
多階層3次元心臓モデルを用いた不整脈誘発性・持続性の評価に関するインシリコ研究 基盤研究(C)
3.
2016/04~2019/03
3次元房室結節モデルによる心拍制御機構解明と心房細動治療戦略のための医工連携研究 基盤研究(C)
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科研費研究者番号
50349792