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Phase I/IIa clinical trial of therapeutic angiogenesis using hepatocyte growth factor gene transfer to treat critical limb ischemia. Arterioscler Thromb Vasc Biol 31(3),713-20頁 (共著) 2011/03 |
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Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. Circulation Research 101(11),1175-1184頁 (共著) 2007 |
3. |
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Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of NFkB and ets transcription factors. Circulation 109,132-138頁 (共著) 2004 |
4. |
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Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets. Gene Therapy 7,417-427頁 (共著) 2000 |
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In Vivo Transfection of cis element "decoy" against NFkB binding site prevented myocardial infarction as gene therapy. Nature Medicine 3,894-899頁 (共著) 1997 |
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Moxibustion Promotes Formation of Granulation in Wound Healing Process through Induction of TGF-β. Chin J Integr Med 26(1),26-32頁 (共著) 2020 |
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Beneficial Effect of Laughter Therapy on Physiological and Psychological Function in the Elderly. 6(1),93-99頁 (共著) 2018 |
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Electric field exposure improves subjective symptoms related to sleeplessness in college students: A pilot study of electric field therapy for sleep disorder. Immunology 17 (共著) 2017 |
9. |
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Therapeutic effect of intra-articular injection of ribbon-type decoy oligonucleotides for hypoxia inducible factor-1 on joint contracture in an immobilized knee animal model. J Gene Med 18(8),180-92頁 (共著) 2016 |
10. |
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Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model. BMC Complement Altern Med 26(16),144頁 (共著) 2016 |
11. |
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Continuous infusion of angiotensin Ⅱ modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. Hypertens Res 38(6),382-393頁 (共著) 2015 |
12. |
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Effect of Angiotensin Ⅱ Receptor Blocker, Olmesartan, on Turnover of Bone Metabolismin Bedridden Elderly Hypertensive Women with Disuse Syndrome. Geriatr Gerontol Int. 15(8),1064-72頁 (共著) 2015 |
13. |
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Anti-Apoptotic Effect of Human Telomerase Reverse Transcriptase on Endothelial Cells under Oxidative Stress, Independent of Telomere Elongation and Telomerase Activity. Immunology 13(2),112-121頁 (共著) 2013 |
14. |
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Anti-inflammatory Effect of Electro-acupuncture via Reduction in Colonic Peristalsis in a Mouse Model of Inflammatory Bowel Disease. Immunology 13(2),122-131頁 (共著) 2013 |
15. |
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Therapeutic effect of ribbon-type nuclear factor-κB decoy oligonucleotides in a rat model of inflammatory bowel disease. Curr Gene Ther 12(6),484-92頁 (共著) 2012/12 |
16. |
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Long-term follow-up evaluation of results from clinical trial using hepatocyte growth factor gene to treat severe peripheral arterial disease. Arterioscler Thromb Vasc Biol 32(10),2503-9頁 (共著) 2012/10 |
17. |
論文 |
Long-term follow-up evaluation of results from clinical trial using hepatocyte growth factor gene to treat severe peripheral arterial disease. Arterioscler Thromb Vasc Biol 31(3),713-20頁 (共著) 2011/03 |
18. |
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Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor κB and Ets Prevents Abdominal Aortic Aneurysm in Rat Model. Mol Ther 19(1),181-7頁 (共著) 2011/01 |
19. |
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Reno-vascular Hypertension is a Severe Risk Factor for Development of Abdominal Aortic Aneurysm. 森ノ宮医療大学紀要 (2号) (共著) 2010 |
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Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis 202(1),34-40頁 (共著) 2009 |
21. |
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Long-term follow up of initial clinical cases with NF-kappaB decoy oligodeoxynucleotide transfection at the site of coronary stenting. J Gene Med 10(7),805-9頁 (共著) 2008/07 |
22. |
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Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkappaB and E2F in a rabbit model. Cardiovascular Research 79(4),706-714頁 (共著) 2008 |
23. |
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Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan. International Journal of Molecular Medicine 22(6),703-708頁 (共著) 2008 |
24. |
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Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase. Journal of Gene Medicine 9(12),1087-1094頁 (共著) 2007 |
25. |
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Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy. Gene Ther 13(16),1206-13頁 (共著) 2006/08 |
26. |
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Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine. Hypertension. 48(1),112-9頁 (共著) 2006/07 |
27. |
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Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappaB and Ets. Hypertension 48(4),628-636頁 (共著) 2006 |
28. |
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Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. Journal of Molecular Cellular Cardiology 41(3),431-440頁 (共著) 2006 |
29. |
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Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model. Gene Therapy 13(8),695-704頁 (共著) 2006 |
30. |
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Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia. Acta Med Okayama. 59(3),73-8頁 (共著) 2005/06 |
31. |
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Development of novel method of non-viral efficient gene transfer into neonatal cardiac myocytes. Journal of Molecular Cellular Cardiology 39(3),503-509頁 (共著) 2005 |
32. |
論文 |
Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model. Gene Therapy 12(14),1109-1118頁 (共著) 2005 |
33. |
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Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther 11(20),1532-9頁 (共著) 2004/10 |
34. |
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Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor. J Hum Hypertens. 18(10),701-5頁 (共著) 2004/10 |
35. |
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Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model. Biochem Biophys Res Commun. 317(2),508-14頁 (共著) 2004/04 |
36. |
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Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation. 109(3),424-31頁 (共著) 2004/01 |
37. |
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In vivo evidence of angiogenesis induced by transcription factor, ets-1: ets-1 is located upstream of angiogenesis cascade. Circulation 109,3035-3041頁 (共著) 2004 |
38. |
論文 |
Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease by therapeutic angiogenesis. Hypertension 44(2),203-209頁 (共著) 2004 |
39. |
論文 |
Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model. Circulation. 108(18),2250-7頁 (共著) 2003/11 |
40. |
論文 |
Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene. FASEB J 17(6),779-81頁 (共著) 2003/04 |
41. |
論文 |
Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1. Circulation 107(10),1411-7頁 (共著) 2003/03 |
42. |
論文 |
Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model. Gene Ther. 10(4),356-64頁 (共著) 2003/02 |
43. |
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HVJ-envelope vector for gene transfer into central nervous system. Biochem Biophys Res Commun 300(2),464-71頁 (共著) 2003/01 |
44. |
論文 |
Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor (HGF). Hypertension Research 27,85-91頁 (共著) 2003 |
45. |
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Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue. J Endocrinol 175(1),217-23頁 (共著) 2002/10 |
46. |
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Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells. Hypertension 40(3),310-4頁 (共著) 2002/09 |
47. |
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Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane. Diabetes 51(8),2604-11頁 (共著) 2002/08 |
48. |
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Molecular strategy using cis-element 'decoy' of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model. Gene Ther 9(8),488-94頁 (共著) 2002/04 |
49. |
論文 |
Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model. Hypertension 39(5),1028-34頁 (共著) 2002/03 |
50. |
論文 |
Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene. Circulation 105(12),1491-6頁 (共著) 2002/03 |
51. |
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Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation. 105(10),1233-9頁 (共著) 2002/03 |
52. |
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Angiogensis and anti-fibrotic action by hepatocyte growth factor in cardiomyopathic hamster. Hypertension 40,47-53頁 (共著) 2002 |
53. |
論文 |
Effective transfection of a cis element "decoy" of the nuclear factor-kappaB binding site into the experimental choroidal neovascularization. Curr Eye Res 24,465-473頁 (共著) 2002 |
54. |
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Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 9,1221-1229頁 (共著) 2002 |
55. |
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cis Element decoy against nuclear factor-kappaB attenuates development of experimental autoimmune myocarditis in rats. Circ Res 89(10),899-906頁 (共著) 2001/11 |
56. |
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Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. Diabetes 50(6),1472-81頁 (共著) 2001/06 |
57. |
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Inhibition of neointima by angiotensin-converting enzyme inhibitor in porcine coronary artery balloon-injury model. Hypertension. 37(2),270-4頁 (共著) 2001/02 |
58. |
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Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension. 37((2 Pt 2)),581-6頁 (共著) 2001/02 |
59. |
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Endothelial apoptosis induced by oxidative stress through activation of NFkB: anti-apoptotic effect of antioxidant agents on endothelial cells. Hypertension 38,48-55頁 (共著) 2001 |
60. |
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Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model. Diabetologia 44,1034-1042頁 (共著) 2001 |
61. |
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Therapeutic angiogenesis induced by hepatocyte growth factor: potential gene therapy for ischemic diseases. Journal of Atherosclerosis and Thrombosis 7,71-76頁 (共著) 2001 |
62. |
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Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models: preclinical study for treatment of peripheral arterial disease. Gene Therapy 8,181-189頁 (共著) 2001 |
63. |
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Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes. Circulation 104,2344-2350頁 (共著) 2001 |
64. |
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Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells. J Hypertens 18(10),1411-20頁 (共著) 2000/10 |
65. |
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In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model. Gene Ther 7(19),1664-71頁 (共著) 2000/10 |
66. |
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Catheter-delivered in vivo gene transfer into rat myocardium using the fusigenic liposomal mediated method. Japanese Heart Journal 41(5),633-47頁 (共著) 2000/09 |
67. |
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Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease. Circulation 102(11),1308-14頁 (共著) 2000/09 |
68. |
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Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation. Circ Res 86(9),974-81頁 (共著) 2000/05 |
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Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21. Hypertension 35(1 Pt 2),237-43頁 (共著) 2000/01 |
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In vivo evidence of importance of cardiac angiotensin converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis 20,428-434頁 (共著) 2000 |
71. |
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Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery resulted in abnormal growth of vascular smooth muscle cells. Circulation 101,1447-1452頁 (共著) 2000 |
72. |
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Inhibition of the p53 tumor suppressor gene resulted in growth of human aortic vascular smooth muscle cells (VSMC): potential role of p53 in regulation of VSMC growth. Hypertension 34,192-200頁 (共著) 1999 |
73. |
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Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells. J Hypertens 16(7),993-1000頁 (共著) 1998/07 |
74. |
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Antisense Cdk2 kinase oligodeoxynucleotide inhibits ICAM-1 expression in murine cardiac allograft arteriopathy. Transplant Proc. 30(1),89-90頁 (共著) 1998/02 |
75. |
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Inhibition of growth of human vascular smooth muscle cells by overexpression of p21 gene through induction of apoptosis. Hypertension 31(1 Pt 2),493-8頁 (共著) 1998/01 |
76. |
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Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene. Gene Ther 5(6),761-9頁 (共著) 1998/01 |
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Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor. Diabetologia 40(9),1053-61頁 (共著) 1997/09 |
78. |
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Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide. Nat Med 3(8),900-3頁 (共著) 1997/08 |
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Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes. Diabetes. 46(1),138-42頁 (共著) 1997/01 |
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Efficient in vivo gene transfer into heart in rat myocardial infarction model using HVJ (Hemagglutinating Virus of Japan)-liposome method. Journal of Molecular and Cellular Cardiology 29,949-959頁 (共著) 1997 |
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Potential role of a novel vascular modulator, hepatocyte growth factor (HGF), in cardiovascular disease: characterization and regulation of local HGF system. J Atheroscler Thromb 4(1),12-9頁 (共著) 1997 |
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Serum deprivation induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells. Heart & Vessels S12,71-75頁 (共著) 1997 |
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Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and b-galactosidase gene in non-infarcted area, but not myocardial infarcted area. Gene Therapy 4,120-127頁 (共著) 1997 |
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Efficient oligonucleotide delivery using the HVJ-liposome method in the central nervous system. Am J Physiol 271(5 Pt 2),R1212-20頁 (共著) 1996/11 |
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Hepatocyte growth factor is a novel member of the endothelium-specific growth factors: additive stimulatory effect of hepatocyte growth factor with basic fibroblast growth factor but not with vascular endothelial growth factor. J Hypertens. 14(9),1067-72頁 (共著) 1996/09 |
86. |
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Sustained transgene expression by transfection of renin gene into liver of neonates. Biochem Biophys Res Commun 224(1),43-9頁 (共著) 1996/07 |
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In vivo gene transfer of insulin gene into neonatal rats by the HVJ-liposome method resulted in sustained transgene expression. Gene Ther 3(6),477-82頁 (共著) 1996/06 |
88. |
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Autocrine-paracrine effects of overexpression of hepatocyte growth factor gene on growth of endothelial cells. Biochem Biophys Res Commun 220(3),539-45頁 (共著) 1996/03 |
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Role of transcriptional cis-elements, angiotensinogen gene-activating elements, of angiotensinogen gene in blood pressure regulation. Hypertension 27(3 Pt 2),502-7頁 (共著) 1996/03 |
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In vivo transfer of gene and oligodeoxynucleotides into skin of fetal rats by incubation in amniotic fluid. Gene Therapy 3,878-885頁 (共著) 1996 |
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Novel strategy of gene therapy in cardiovascular disease with HVJ-liposome method. Contrib Nephrol 118,254-64頁 (共著) 1996 |
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Effect of angiotensinogen on blood pressure regulation in normotensive rats: application of a loss of function approach. J Hypertens 13(12 Pt 2),1767-74頁 (共著) 1995/12 |
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Transient decrease in high blood pressure by in vivo transfer of antisense oligodeoxynucleotides against rat angiotensinogen. Hypertension 26(1),131-6頁 (共著) 1995/07 |
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