教員データベース - 久保　忠彦

1.	1983/04～1989/03	広島大学医学部医学科卒業
2.	1997/04～2001/03	広島大学大学院医学系研究科博士課程外科系（整形外科学）専攻博士課程修了医学博士

■ 職歴

1.	1989/06	広島大学医学部附属病院整形外科医員（研修医）
2.	1989/10	土肥整形外科常勤医師
3.	1990/04	マツダ病院整形外科医師
4.	1992/04	国立大竹病院整形外科医師
5.	1995/04	庄原赤十字病院整形外科医師
6.	1996/04	中国労災病院整形外科医師
7.	2001/04	米国Memorial Sloan-Kettering Cancer Center (New York, NY) 研究員
8.	2003/01	広島大学医学部附属病院整形外科医員
9.	2005/04	広島大学大学院　整形外科　広島大学助手
10.	2007/04	広島大学大学院　整形外科　広島大学助教
11.	2008/11	広島大学病院整形外科非常勤講師
12.	2016/03	広島大学大学院　整形外科　広島大学准教授
13.	2020/04	森ノ宮医療学園附属みどりの風クリニック院長
14.	2020/06～	森ノ宮医療大学大学院保健医療学研究科保健医療学専攻教授
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■ 専門分野

整形外科学, 骨・軟部腫瘍学

■ 研究テーマ

1.	Deep learning AIを用いた画像診断法の開発
2.	悪性骨軟部腫瘍治療のための分子標的の探索
3.	殺腫瘍ウイルス治療法の開発

■ 所属学会

1.	1989～	中国・四国整形外科学会
2.	2017～	∟ 代議員
3.	1989～	中部日本整形外科災害外科学会
4.	2015～	∟ 評議員
5.	1989～	日本整形外科学会
6.	2015～	∟ 中国・四国地区資格認定委員
7.	1997～	骨軟部肉腫治療研究会
8.	2015～2020	∟ 幹事
9.	1997～	山陽骨軟部腫瘍研究会
10.	2015～2020	∟ 幹事
11.	1997～	日本癌学会
12.	2008～	日本臨床腫瘍学会
13.	2017～	日本サルコーマ治療研究学会
14.	2017～2020	∟ 評議員
15.	2018～	整形災害外科学研究助成財団選考委員会委員
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■ 受賞学術賞

1.	2018/03	Travel Award in Orthopaedic Research Translation
2.	2017/07	インドネシア骨軟部腫瘍学会 1st Winner of Poster Presentation
3.	2010/03	アメリカ整形外科臨床学会 2010 Best Poster Awards
4.	2009/06	American Orthopaedic Association(アメリカ整形外科学会)/Japanese Orthopaedic Association Traveling Fellow
5.	2004/03	2004 New Investigator Recognition Awards
6.	2003/02	アメリカ整形外科基礎学会 2003 New Investigator Recognition Awards
7.	2000/10	British Orthopaedic Association（イギリス整形外科学会）, Japanese Orthopaedic Association Traveling Fellow
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■ 論文

1.	論文	A meta-analysis supports core needle biopsy by radiologists for better histological diagnosis in soft tissue and bone sarcomas. Medicine (Baltimore) 97,e11567頁（共著） 2018
2.	論文	Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. World J Surg Oncol 16,160頁（共著） 2018
3.	論文	Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma. J Orthop Res （共著） 2018
4.	論文	Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma. Sci Rep 7,40187頁（共著） 2017
5.	論文	Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results. Inorg Chem 56,7558-7565頁（共著） 2017
6.	論文	Sluggish speed signs on ultrasound are novel indicators of hemangiomas. Acta Radiol 58,1231-1237頁（共著） 2017
7.	論文	Feasibility and efficacy of gemcitabine and docetaxel combination chemotherapy for bone and soft tissue sarcomas: multi-institutional retrospective analysis of 134 patients. World J Surg Oncol 14,306頁（共著） 2016
8.	論文	More than 20-year Follow-Up After Vascularised Fibula Head Graft for Oncological Shoulder Joint Reconstruction. Anticancer Res 36,301-305頁（共著） 2016
9.	論文	Percent slope analysis of dynamic magnetic resonance imaging for assessment of chemotherapy response of osteosarcoma or Ewing sarcoma: systematic review and meta-analysis. Skeletal Radiol 45,1235-1242頁（共著） 2016
10.	論文	Prognostic significance of (18)F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma; systematic review and meta-analysis. Eur J Cancer 58,104-111頁（共著） 2016
11.	論文	Value of diffusion-weighted imaging for evaluating chemotherapy response in osteosarcoma. Mol Clin Oncol 7,88-92頁（共著） 2016
12.	論文	Does expression of glucose transporter protein-1 relate to prognosis and angiogenesis in osteosarcoma? Clin Orthop Relat R 473,305-310頁（共著） 2015
13.	論文	Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line. Chem-Eur J 21,10537-10547頁（共著） 2015
14.	論文	Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: systematic review and meta-analysis. Crit Rev Oncol Hematol 96,46-53頁（共著） 2015
15.	論文	Prognostic value of SS18-SSX fusion type in synovial sarcoma; systematic review and meta-analysis. Springerplus. 4,375頁（共著） 2015
16.	論文	Quantitative 201thallium scintigraphy for prediction of histological response to neoadjuvant chemotherapy in osteosarcoma; systematic review and meta-analysis. Surg Oncol 24,194-199頁（共著） 2015
17.	論文	A novel assessment method of serum alkaline phosphatase for the diagnosis of osteosarcoma in children and adolescents. J Orthop Sci 19,997-1003頁（共著） 2014
18.	論文	Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem Bioph Res Co 455,381-387頁（共著） 2014
19.	論文	Therapeutic effect and risk factors for complications of excision in 76 patients with schwannoma. J Orthop Sci 19,150-155頁（共著） 2014
20.	論文	Diversity of angiogenesis among malignant bone tumors. Mol Clin Oncol 1,131-136頁（共著） 2013
21.	論文	Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas. J Exp Clin Canc Res 31,5頁（共著） 2012
22.	論文	Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res 29,1707-1711頁（共著） 2011
23.	論文	Interferon-α/β receptor as a prognostic marker in osteosarcoma. J Bone Joint Surg Am 93,519-526頁（共著） 2011
24.	論文	Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth. 29,795-800頁（共著） 2011
25.	論文	Alternative lengthening of telomeres as a prognostic factor in malignant fibrous histiocytomas of bone. Anticancer Res 30,4959-4962頁（共著） 2010
26.	論文	Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: a X-ray and NMR investigation. J Am Chem Soc 131,5153-5162頁（共著） 2009
27.	論文	Telomere-maintenance mechanisms in soft-tissue malignant fibrous histiocytomas. J Bone Joint Surg Am 91,928-937頁（共著） 2009
28.	論文	Differential diagnosis between osteomyelitis and bone tumors. Acta Radiol 49,928-933頁（共著） 2008
29.	論文	Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemoth Pharm 62,111-116頁（共著） 2008
30.	論文	Expression of hypoxia-inducible factor-1α and its relationship to tumor angiogenesis and cell proliferation in cartilage tumors. Bone Joint J (J Bone Joint Surg Br) 90,364-370頁（共著） 2008
31.	論文	Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas. J Exp Clin Canc Res 27-73頁（共著） 2008
32.	論文	Osteoprogenitor differentiation is not affected by immunomodulatory thalidomide analogs but is promoted by low bortezomib concentration, while both agents suppress osteoclast. differentiation. Int J Oncol 33,129-136頁（共著） 2008
33.	論文	Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. Cancer 112,2119-2129頁（共著） 2008
34.	論文	Connective tissue growth factor is an indicator of bone involvement in multiple myeloma, but matrix metalloproteinase-9 is not. Brit J Haematol 139,41-50頁（共著） 2007
35.	論文	Major-nerve schwannomas versus intramuscular schwannomas. Acta Radiol 48,672-677頁（共著） 2007
36.	論文	Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer 121,943-954頁（共著） 2007
37.	論文	Telomerase activity in giant cell tumors of bone. Ann Surg Oncol 14,2896-2902頁（共著） 2007
38.	論文	Telomere length and telomerase activity in extra-abdominal desmoid tumors. Anticancer Res 27,411-415頁（共著） 2007
39.	論文	Conservative surgery for well-differentiated liposarcomas of the extremities adjacent to major neurovascular structures. Surg Oncol 15,167-171頁（共著） 2006
40.	論文	Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells. J Orthop Res 24,1138-1144頁（共著） 2006
41.	論文	Cell proliferation of cultured human cancer cells are affected by the elevated tumor pressures that exist in vivo. Ann Biomed Eng 33,1270-1280頁（共著） 2005
42.	論文	Clinical outcomes of 54 pelvic osteosarcoma registered by Japanese Musculo-skeletal Oncology Group. Oncology 68,375-381頁（共著） 2005
43.	論文	Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model. J Biomed Mater Res A 73,255-263頁（共著） 2005
44.	論文	Nerve tolerance to high-dose-rate brachytherapy in patients with soft tissue sarcoma: a retrospective study. BMC Cancer 5-79頁（共著） 2005
45.	論文	Reconstructed patellar tendon length after proximal tibia prosthetic replacement. Clin Orthop Relat R 439,176-180頁（共著） 2005
46.	論文	Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res 64,2734-2739頁（共著） 2004
47.	論文	Evaluation of systemic chemotherapy with magnetic liposomal doxorubicin and a dipole external electromagnet. Int J Cancer 109,67-635頁（共著） 2004
48.	論文	Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. Int J Cancer 109,106-111頁（共著） 2004
49.	論文	Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma. Biomagn Res Technol 2-3頁（共著） 2004
50.	論文	Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. J Biomed Mater Res A 66,747-754頁（共著） 2003
51.	論文	Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field. Int J Oncol 22,1065-1071頁（共著） 2003
52.	論文	Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma. Int J Oncol 19,585-589頁（共著） 2001
53.	論文	Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters. Int J Oncol 18,121-125頁（共著） 2001
54.	論文	Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters. Int J Oncol 17,309-315頁（共著） 2000
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■ 著書

1.	著書	Telomere maintenance mechanisms in bone and soft tissue tumors. In: Leonardo Mancini Ed. Telomeres: Function, Shortening and Lengthening 391-402頁（共著） 2009
2.	著書	Brachytherapy for soft tissue sarcomas. In: Sôta Hasegawa Ed. Soft Tissue Cancers: Etiology, Pathogenesis and Interventions 121-134頁（共著） 2008

■ 総説等

1.	その他	Minodronate for the treatment of osteoporosis. Drugs Today (Barc) 46,33-37頁（共著） 2010
2.	その他	Telomeres and telomerase in sarcomas. Anticancer Res 29,3833-3836頁（共著） 2009

■ 学会発表

1.	2018	MR/US Fusion Image as a modality for determination of safe tumor margin in malignant musculoskeletal tumors.（The 28th Japan-Korean Combined Orthopaedic Symposium (JKCOS 2018)）
2.	2018	Near-infrared fluorescent tumor cell detection by tumor-specific virus VSV for precise osteosarcoma resection.（The 2018 Annual Meeting of Orthopaedic Research Society）
3.	2018	The Theranostic Potential of Vesicular Stomatitis Virus for Metastatic Inhibition and Circulating Tumor Cell Imaging in Osteosarcoma Syngeneic Mouse Model.（The 2018 Annual Meeting of Orthopaedic Research Society）
4.	2017	MRI/US fusion image as a modality for determination of safe tumor margin in musculoskeletal tumors.（The 3rd National Congress of Indonesian Musculoskeletal Tumor Society）
5.	2017	Resection design of a malignant bone tumor using MRI/US fusion imaging.（The 19th International Society of Limb Salvage）
6.	2016	Prognostic Significance of Positron Emission Tomography in Patients with Sarcoma.（The 2016 Annual Meeting of American Academy of Orthopaedic Surgeons）
7.	2015	Clinical significance of serum acid phosphatase as a tumor marker in giant cell tumor of bone.（The 2015 Annual Meeting of American Academy of Orthopaedic Surgeons）
8.	2014	Expression and role of glucose transporter protein-1 in osteosarcoma.（The 2014 Annual Meeting of American Academy of Orthopaedic Surgeons）
9.	2012	Cancer Immunotherapy with Novel Bisphosphonates for Bone Metastasis.（The 2012 Annual Meeting of American Academy of Orthopaedic Surgeons）
10.	2011	Diversity of angiogenesis among malignant bone tumors.（The 2011 Annual Meeting of American Academy of Orthopaedic Surgeons）
11.	2011	Expression of p38 and human telomerase transcriptase in 90 sarcomas.（The 2011 Annual Meeting of American Academy of Orthopaedic Surgeons）
12.	2010	Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines.（The 56th Annual Meeting of Orthopaedic Research Society）
13.	2010	Expression of p38 MAPK and human telomerase reverse transcriptase in liposarcomas and osteosarcomas.（The 7th Combined Meeting of Orthopaedic Research Society.）
14.	2010	Expression of promyelocytic leukemia body and human telomerase reverse transcriptase in 82 sarcomas.（The 2010 Annual Meeting of American Academy of Orthopaedic Surgeons）
15.	2010	Type I interferon receptor as a prognostic marker in osteosarcoma.（The 56th Annual Meeting of Orthopaedic Research Society）
16.	2010	Type I interferon receptor as a prognostic marker in osteosarcoma.（The 2010 Annual Meeting of American Academy of Orthopaedic Surgeons）
17.	2009	Angiogenesis in bone sarcoma.（American Orthopaedic Association / Japanese Orthopaedic Association Traveling Fellow）
18.	2009	Interferons and osteosarcoma.（American Orthopaedic Association / Japanese Orthopaedic Association Traveling Fellow,）
19.	2009	Isolated limb perfusion of oncolytic vesicular stomatitis virus to extremity sarcoma in immune-competent rats.（The 55th Annual Meeting of Orthopaedic Research Society）
20.	2009	New bisphosphonates for sarcoma therapy.（American Orthopaedic Association / Japanese Orthopaedic Association Traveling Fellow）
21.	2008	Analysis of telomerase factors in 86 human sarcomas.（The 2008 Annual Meeting of American Academy of Orthopaedic Surgeons）
22.	2008	Expression of HIF and its relationship to angiogenesis and cell proliferation in cartilage tumors.（The 2008 Annual Meeting of American Academy of Orthopaedic Surgeons）
23.	2008	Telomerase maintenance mechanisms in mesenchymal tumors.（International Conference of Anticancer Research）
24.	2007	Clinical experiences of implantation of beta-tricalcium phosphate for benign bone tumors.（The 14th International Symposium of Limb Salvage）
25.	2006	Analysis of telomerase activity in 42 malignant fibrous histiocytomas.（The 2006 Annual Meeting of American Academy of Orthopaedic Surgeons）
26.	2006	Efficacy of the third-generation bisphosphonates in conjunction with doxorubicin or p38 inhibitor against osteosarcoma and Ewing’s sarcoma cells.（The 52th Annual Meeting of Orthopaedic Research Society）
27.	2005	Analysis of telomerase activity and telomere length in giant cell tumors of bone.（The 13th International Symposium of Limb Salvage）
28.	2005	Inhibitory Effect of the Third-generation Bisphosphonates on Proliferation and Invasion of Osteosarcoma and Chondrosarcoma Cells.（The 51th Annual Meeting of Orthopaedic Research Society）
29.	2004	WNT signaling in osteosarcoma: potential novel targets for prevention of tumor metastasis.（The 50st Annual Meeting of Orthopaedic Research Society）
30.	2003	Management of pelvic osteosarcoma in Japan.（The 12th International Symposium of Limb Salvage）
31.	2003	Platelet-derived growth factor receptors as novel molecular target for therapeutic intervention using STI571 in osteosarcoma.（The 49st Annual Meeting of Orthopaedic Research Society）
32.	2002	Growth inhibition of platelet-derived growth factor-mediated osteosarcoma cells by STI571.（The 93rd Annual Meeting of American Association for Cancer Research）
33.	2000	Anti-tumour effect on hamster osteosarcoma by new chemotherapeutic system with magnetic liposomes.（The 1st British Orthopaedic Association / Japanese Orthopaedic Association Combined Congress）
34.	2000	CT guided percutaneous transcortical resection for osteoid osteoma.（The 3rd Meeting of Asia Pacific Musculoskeletal Tumor Society）
35.	2000	Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters.（The 3rd Meeting of Asia Pacific Musculoskeletal Tumor Society）
36.	2000	Vascularized bone transfer for reconstruction after aggressive musculoskeletal tumor resection.（The 1st British Orthopaedic Association / Japanese Orthopaedic Association Combined Congress）
37.	1999	41. Nitta Y, Ikuta Y, Sugita T, Shimose S, Kubo T. 1999, Two cases of satisfactory limb salvage of desmoplastic fibroma of bone using by vascularized fibular graft following wide resection.（The 10th International Symposium on Limb Salvage）
38.	1999	Adjuvant brachytherapy for soft tissue sarcoma of the extremities.（U.S. Cancer Therapy Symposium in Hiroshima）
39.	1999	Reconstruction for benign tumor of the femoral head and neck with vascularized bone graft.（The 10th International Symposium on Limb Salvage）
40.	1999	Targeting therapy for osteosarcoma using thermosensitive liposome-encapsulated doxorubicin in hamsters.（SIROT (International Research Society of Orthopaedic Surgery and Traumatology)）
41.	1999	The clinical features of diagnosis and prognosis of alveolar soft part sarcoma.（The 10th International Symposium on Limb Salvage）
42.	1998	Adjuvant brachytherapy for soft tissue sarcoma.（The 2nd Meeting of Asian-Pacific Musculoskeletal Tumor Society）
43.	1998	Application of three -dimensional computed tomography in bone and soft tissue tumors.（The 2nd Meeting of Asian-Pacific Musculoskeletal Tumor Society）
44.	1998	Follow-up study of osteosarcoma.（The 2nd Meeting of Asian-Pacific Musculoskeletal Tumor Society）
45.	1998	Lung metastasis inhibitory effect and optimal dosage of muramyl dipeptide (MDP) analogue on hamster’s osteosarcoma.（The 3rd Combined Meeting of Orthopaedic Research Societies of USA, Canada, Europe, and Japan）
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■ 外部資金

1.	2018/04～2019/03	Prognostic significance of 18F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma.
2.	2017/04～2018/03	More than 20-year follow-up after vascularised fibula head graft for oncological shoulder joint reconstruction
3.	2017/04～2018/03	高悪性度骨軟部腫瘍に対する標準治療確立のための研究その他の補助金・助成金
4.	2016/04～2019/03	microRNAエンコーディング腫瘍溶解性ウイルスによる多段階的悪性腫瘍治療戦略基盤研究（C）
5.	2016/04～2017/03	STRUCTURE, FUNCTION AND INHIBITION OF [4FE-4S] PROTEINS
6.	2016/04～2017/03	高悪性度骨軟部腫瘍に対する標準治療確立のための研究その他の補助金・助成金
7.	2015/04～2016/03	高悪性度骨軟部腫瘍に対する標準治療確立のための研究その他の補助金・助成金
8.	2014/04～2015/03	STRUCTURE, FUNCTION AND INHIBITION OF [4FE-4S] PROTEINS
9.	2014/04～2017/03	鏡視下腫瘍広範切除のための新しい蛍光バイオイメージングの開発基盤研究（C）
10.	2012/04～2015/03	miRNAを含むエクソソームを用いた骨腫瘍治療への応用基盤研究（C)
11.	2009/04～2012/03	転移性骨腫瘍に対する次世代ビスフォスフォネートを用いた磁気ターゲッティング療法基盤研究（C)
12.	2008/04～2009/03	PRENYLDIPHOSPHATE SYNTHASE INHIBITORS
13.	2008/04～2011/03	テロメラーゼ阻害剤封入磁性体リポソームと外磁場による骨・軟部肉腫ターゲット治療基盤研究（C）
14.	2008/04～2011/03	多血小板血漿を用いた細胞増殖因子の標的治療による骨再生基盤研究（C）
15.	2006/04～2008/03	癌細胞が取り込む陽電子放射断層撮影用薬剤を応用したリポソームによる抗癌剤標的治療基盤研究（C）
16.	2006/04～2008/03	四肢悪性腫瘍に対する新しい殺腫瘍ウイルス・デリバリー・システムの開発基盤研究（C）
17.	2004/04～2006/03	磁気ターゲッティングを用いた第三世代ビスフォスフォネートによる悪性骨腫瘍治療基盤研究（C）
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